Journal of Research in Medical Sciences

REVIEW ARTICLE
Year
: 2021  |  Volume : 26  |  Issue : 1  |  Page : 23-

The role of antiresorptive drugs and medication-related osteonecrosis of the jaw in nononcologic immunosuppressed patients: A systematic review


Roberto Sacco1, Julian Woolley2, Julian Yates1, Monica Diuana Calasans-Maia3, Oladapo Akintola2, Vinod Patel4 
1 The University of Manchester, Division of Dentistry, School of Medical Sciences, Oral Surgery Department, Manchester, UK
2 King's College Dental Hospital, Oral Surgery Department, London, UK
3 Universidade Federal Fluminense, Dental School, Oral Surgery Department, Rio de Janeiro, Brazil
4 Guy's Dental Hospital, Oral Surgery Department, London, UK

Correspondence Address:
Dr. Roberto Sacco
Division of Dentistry, Manchester University, Coupland 3 Building, Oxford Road, Manchester M13 9PL
UK

Medication related osteonecrosis of the jaw (MRONJ) is a severe condition affecting the jaws of patients exposed to specific drugs, and is primarily described in patients receiving bisphosphonate (BP) therapy. However, more recently it has been observed in patients taking other medications, such as the RANK ligand inhibitor (denosumab) and antiangiogenic drugs. It has been proposed that the existence of other concomitant medical conditions may increase the incidence of MRONJ. The primary aim of this research was to analyze all available evidence and evaluate the reported outcomes of osteonecrosis of the jaws (ONJ) due to antiresorptive drugs in immunosuppressed patients. A multi-database (PubMed, MEDLINE, EMBASE and CINAHL) systematic search was performed. The search generated twenty-seven studies eligible for the analysis. The total number of patients included in the analysis was two hundred and six. All patients were deemed to have some form of immunosuppression, with some patients having more than one disorder contributing to their immunosuppression. Within this cohort the commonest trigger for MRONJ was a dental extraction (n=197). MRONJ complications and recurrence after treatment was sparsely reported in the literature, however a total of fourteen cases were observed. The data reviewed have confirmed that an invasive procedure is the commonest trigger of MRONJ with relatively high frequency of post-operative complications or recurrence following management. However, due to low-quality research available in the literature it is difficult to draw a definitive conclusion on the outcomes analysed in this systematic review.


How to cite this article:
Sacco R, Woolley J, Yates J, Calasans-Maia MD, Akintola O, Patel V. The role of antiresorptive drugs and medication-related osteonecrosis of the jaw in nononcologic immunosuppressed patients: A systematic review.J Res Med Sci 2021;26:23-23


How to cite this URL:
Sacco R, Woolley J, Yates J, Calasans-Maia MD, Akintola O, Patel V. The role of antiresorptive drugs and medication-related osteonecrosis of the jaw in nononcologic immunosuppressed patients: A systematic review. J Res Med Sci [serial online] 2021 [cited 2021 Apr 17 ];26:23-23
Available from: https://www.jmsjournal.net/article.asp?issn=1735-1995;year=2021;volume=26;issue=1;spage=23;epage=23;aulast=Sacco;type=0