Journal of Research in Medical Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 25  |  Issue : 1  |  Page : 25-

TP53 rs1042522 polymorphism and early-onset breast cancer


Irmak Icen-Taskin1, Sevgi Irtegun-Kandemir2, Omer Munzuroglu3 
1 Department of Molecular Biology and Genetics, Faculty of Science and Art, Inonu University, Malatya, Turkey
2 Department of Medical Biology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey
3 Department of Bioengineering, Faculty of Engineering, Firat University, Elazig, Turkey

Correspondence Address:
Dr. Sevgi Irtegun-Kandemir
Department of Medical Biology, Faculty of Medicine, Dicle University, Diyarbakir 21280
Turkey

Background: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms. TP53 rs1042522 polymorphism relates to the risk of breast neoplasms, but this relationship in Turkish early-onset breast cancer patients has not been investigated yet. We aimed to search the relationship between TP53 rs1042522 polymorphism and young Turkish breast cancer patients. Materials and Methods: Ninety-six female breast cancer patients who were ≤ 40 years of age and 96 healthy controls were enrolled in our study. Participants were genotyped by the hybridization probe system. Results: We identified that the genotype frequencies of rs1042522 were significantly different between controls and cases (P = 0.027). Participants carrying CG genotype had also reduced breast cancer risk (odds ratio = 0.4196, 95% confidence interval: 0.1941–0.9067, P= 0.027). Our results revealed that there is an association between GG and CG + CC genotype groups with progesterone receptor (PgR) status (P = 0.0219). Conclusion: Our findings indicate that the CG genotype is a protective factor against breast neoplasms. No other clinicopathologic parameters except for PgR status were found to be related to rs1042522 polymorphism in young Turkish breast cancer patients.


How to cite this article:
Icen-Taskin I, Irtegun-Kandemir S, Munzuroglu O. TP53 rs1042522 polymorphism and early-onset breast cancer.J Res Med Sci 2020;25:25-25


How to cite this URL:
Icen-Taskin I, Irtegun-Kandemir S, Munzuroglu O. TP53 rs1042522 polymorphism and early-onset breast cancer. J Res Med Sci [serial online] 2020 [cited 2021 Mar 1 ];25:25-25
Available from: https://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=25;epage=25;aulast=Icen-Taskin;type=0