Journal of Research in Medical Sciences

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 21  |  Issue : 1  |  Page : 47-

The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events


Rokhsareh Meamar1, Hamidreza Nikyar3, Leila Dehghani2, Maedeh Talebi3, Marzieh Dehghani4, Marzieh Ghasemi4, Behnaz Ansari5, Mohammad Saadatnia5 
1 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences; Endocrine and Metabolism Research Center; Department of Medical Sciences, School of Medicine, Najafabad Branch, Islamic Azad University, Isfahan, Iran
2 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences; School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Biochemistry, Biochemistry Laboratory, Alzahra Hospital, Isfahan University of Medical Sciences,Isfahan, Iran
4 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
5 Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences; Department of Neurology, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Rokhsareh Meamar
Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan
Iran

Background: The role of endothelial progenitor cells (EPCs) in the maintenance of vascularization following ischemic brain after experimental stroke has been established. Accordingly, in this study, we evaluated the role of circulating EPCs in transient ischemic attack (TIA) patients for future cerebrovascular (CV) events. Materials and Methods: The level of circulating EPCs (staining markers: CD34, CD309) were determined using flow cytometry at 24 h after TIA in thirty consecutive patients. The EPCs level was also evaluated once in thirty healthy volunteers. Over a period of 12 months, all patients were evaluated by an experienced neurologist for recurrent TIA, stroke or death induced by CV disorders. Results: Circulating EPCs increased in patients group following the first attack of TIA when compared with controls. By analysis of covariance, cardiovascular event history, hyperlipidemia, and statin therapy remained significant independent predictors of EPCs. The mean (standard deviation) duration of follow-up was 10.5 (3.1) months (range, 2–12 months). During follow-up, a total of three patients died due to CV accident and four patients experienced again recurrent TIA. By analyzing data with Cox regression, EPC did not predict the future CV events in TIA patients. Conclusion: Increased incidence of future CV events did not occur in those patients with elevated EPCs in the first attack of TIA. The significant predicting factors of EPCs were cardiovascular event history, hyperlipidemia, and statin therapy.


How to cite this article:
Meamar R, Nikyar H, Dehghani L, Talebi M, Dehghani M, Ghasemi M, Ansari B, Saadatnia M. The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events.J Res Med Sci 2016;21:47-47


How to cite this URL:
Meamar R, Nikyar H, Dehghani L, Talebi M, Dehghani M, Ghasemi M, Ansari B, Saadatnia M. The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events. J Res Med Sci [serial online] 2016 [cited 2020 Oct 21 ];21:47-47
Available from: https://www.jmsjournal.net/article.asp?issn=1735-1995;year=2016;volume=21;issue=1;spage=47;epage=47;aulast=Meamar;type=0