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ORIGINAL ARTICLE
Year : 2020  |  Volume : 25  |  Issue : 1  |  Page : 91

The ameliorating effects of Vitamin E on hepatotoxicity of ecstasy


1 Department of Anatomy, Urmia University of Medical Sciences, Urmia, IR Iran
2 Department of Biochemistry, Urmia University of Medical Sciences, Urmia, IR Iran
3 Student Research Committee, Urmia University of Medical Sciences, Urmia, IR Iran

Correspondence Address:
Dr. Khadije Meghrazi
Faculty of Medicine, 11 Kilometer of Nazlou Road, Urmia
IR Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_496_19

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Background: The production of stress oxidative condition in body which is caused by consumption of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) leads to a liver damage. As an antioxidant, Vitamin E can protect cells and tissues against the deleterious effects of free radicals. This study evaluates the protective effects of Vitamin E on MDMA induced liver toxicity. Materials and Methods: Twenty-eight male albino mice were randomly assigned to four equal groups. Group 1 received saline (control), Group 2 received MDMA and saline, Group 3 received MDMA, and Vitamin E and Group 4 received Vitamin E. MDMA was injected with single daily dose, three sequential days/week for 5 weeks. At the end of the period, blood samples were collected for a biochemical analysis and then the mice were sacrificed by cervical dislocation for histopathological and biochemical examinations of liver. Results: The administration of Vitamin E attenuated the increased levels of alanine transaminase, aspartate transaminase, and alkaline phosphatase enzymes in serum. Vitamin E treatments significantly restored endogenous antioxidant enzymes (reduced glutathione and superoxide dismutase enzyme) activities as compared with MDMA-treated animals. Histological examination of liver revealed significant morphological tissue injuries in hepatocytes after MDMA being used, but in coadministration of vitamin E and MDMA, these morphological alterations reduced. Conclusion: The study showed that MDMA administration has adverse effects on the liver. Vitamin E lessened the deleterious impact considerably.


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