Revisional surgery after one anastomosis/mini gastric bypass: A narrative review
Mohammad Kermansaravi1, Kamal Kumar Mahawar2, Amir Hosein Davarpanah Jazi3, Foolad Eghbali1, Ali Kabir4, Abdolreza Pazouki1
1 Minimally Invasive Surgery Research Center, Iran University of Medical Sciences; Center of Excellence of European Branch of International Federation for Surgery of Obesity, Hazrat-e Rasool Hospital, Tehran, Iran
2 Department of General Surgery, Bariatric Unit, Sunderland Royal Hospital, Sunderland, England, United Kingdom
3 Minimally Invasive Surgery Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran
|Date of Submission||25-Sep-2019|
|Date of Decision||16-Feb-2020|
|Date of Acceptance||11-Mar-2020|
|Date of Web Publication||30-Jun-2020|
Dr. Amir Hosein Davarpanah Jazi
Minimally Invasive Surgery Research Center, Isfahan University of Medical Sciences, Isfahan
Source of Support: None, Conflict of Interest: None
One anastomosis gastric bypass (OAGB)/mini gastric bypass is now considered to be a safe and efficient method for morbidly obese patients but has complications and adverse events such as other surgical procedures. The present paper outlines the need for and the nature of revisional surgery in the long-term following OAGB in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines. A literature search was carried out in PubMed. All articles on OAGB for which the authors described a patient needing revisional surgery in the long term after OAGB were examined.
Keywords: Bariatric surgery, gastroesophageal reflux disease, malnutrition, marginal ulcer, morbid obesity, one anastomosis gastric bypass, revisional surgery, weight regain
|How to cite this article:|
Kermansaravi M, Mahawar KK, Davarpanah Jazi AH, Eghbali F, Kabir A, Pazouki A. Revisional surgery after one anastomosis/mini gastric bypass: A narrative review. J Res Med Sci 2020;25:62
|How to cite this URL:|
Kermansaravi M, Mahawar KK, Davarpanah Jazi AH, Eghbali F, Kabir A, Pazouki A. Revisional surgery after one anastomosis/mini gastric bypass: A narrative review. J Res Med Sci [serial online] 2020 [cited 2020 Oct 30];25:62. Available from: https://www.jmsjournal.net/text.asp?2020/25/1/62/288701
| Introduction|| |
One anastomosis gastric bypass (OAGB) is now recognized as an effective and established bariatric and metabolic procedure by global community of bariatric surgeons., It has many potential advantages such as technical ease, shorter operative time, lower complication rates, simpler revision and reversal, and lower incidence of internal herniation over Roux-en-Y gastric bypass (RYGB), the longest serving bariatric procedure.,,,
Regardless of these advantages, about 4% patients need revisional/reversal surgeries in the long-term after OAGB due to protein-calorie malnutrition and/or excessive weight loss, persistent gastroesophageal reflux disease (GERD), persistent marginal ulcer (MU), inadequate weight loss, or weight regain. Revisions for complications have been reported in about 1%–2% patients for GERD,,, 0%–2% for MUs,, 0%–1.01% for severe malnutrition, and about 0.5% for incomplete weight loss and weight regain.,,,,,,,,,
Despite the worldwide increasing popularity of OAGB, there are some concerns about its long-term complications, and there is currently no consensus on the management of these complications. There is further no systematic review in the literature attempting to understand the need for revisional surgery for complication management and inadequate therapeutic response after this procedure. This poses difficulties for individual surgeons when they have to deal with these problems in their individual practice.
The aim of this review was to understand the need and the nature of the revisional surgery in the long-term following OAGB in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines.
| Methods|| |
We performed a search in PubMed and EMBASE with using one or more of keywords such as “OAGB,” “Mini gastric bypass (MGB),” “omega loop gastric bypass,” “single anastomosis gastric bypass,” “Revision,” “reversal,” “redo,” “severe malnutrition,” “protein-calorie malnutrition,” “GERD,” “GERD,” “GERD,” “GORD,” “acid reflux,” bile reflux,” “Reflux”, “Severe weight loss,” “insufficient weight loss” “MU,” “anastomotic ulcer,” “Ulcer,” “complication” to find all articles on OAGB where authors described any patient needing revisional surgery in the long term-after OAGB.
This review focuses only on revisional surgeries for MU, GERD, malnutrition, weight regain and inadequate weigh loss after OAGB. Any related articles specifically addressing revisional surgeries in patients undergoing OAGB, including original articles, case reports, and video reports were retrieved and included in this review. All articles published until November 31, 2018 were included. We found all reported series of OAGB, and after considering repeated results in timely reported results by the same team, finally, 17,166 reported cases of OAGB included in this review. We tried to find the causes of surgical revision of OAGB due to complications related to operation. MU (83/17,166), GERD (219/17,166), malnutrition (144/17,166), and weigh regain/inadequate weigh loss (19/4010) were the most reported complication in the reported series.
We excluded surgery for early complications after OAGB, as the purpose of this review was to understand the need and nature for long-term revisions after OAGB with an overall aim of reducing these complications in the future. Non-English language articles were also excluded.
| Results|| |
The incidence of MU after OAGB is reported from 0.2% to 8% in different studies,,,,,,,,,,,,, that is comparable with RYGB. It seems that the long narrow pouch in OAGB can be an important factor to the prevention of MU, because of bufferization of gastric acid with bile stream. Furthermore, the use of absorbable suture in anastomosis, performing retrogastric gasterojejunostomy, prophylactic proton pomp inhibitors (PPIs) prescription for at least 6 months but preferably longer after OAGB, can have preventive effects in MU [Table 1].
Some authors recommend PPIs and antibiotics as the first-line treatment of MU.,,,, In resistant and bleeder MUs, revisional procedures are suggested such as conversion to RYGB,,,,,,, conversion to sleeve gastrectomy (SG), and other procedures such as Braun jejunojejunostomy, anastomosis revision, or complete reversal., In perforated MU, laparoscopic or open repair with omental patch and drainage are mentioned.,,,
Gastro-esophageal reflux disease
There is a big fear of post OAGB GERD in some bariatric surgeon, it may be under-reported; however, there is not any evidence about its carcinogenic effect on stomach and esophagus. Indeed not only OAGB by preserving the gastroesophageal junction function does not make reflux but also leads to decreased reflux episodes due to less exposure between gastric acid and esophagus. On the other hand, large jejunal loop can increase the lower esophageal sphincter pressure and a dependent gasterojejunostomy in OAGB,, lead to prevention of GERD. There is a physiologic condition named duodenogastric reflux which only in disabling symptoms, the medical and surgical interventions are indicated.
The incidence of post-OAGB GERD has been reported from 0% to 30% in different studies.,,,,,,,,,,,,
Carbajo et al., in their study, concluded that their modification in OAGB can decrease the postoperative GERD incidence to zero however this modification is not essential, based on first consensus statement of OAGB.
There are some reports about GERD improvement after OAGB. Rutledge and Walsh resulted in GERD improvement after OAGB in 77% and 85% of GERD suffering patients in two studies., Carbajo et al. also reported GERD improvement in 100% of patients after OAGB.
In the presence of medical resistant GERDs that usually are seen about 2 years after OAGB, revisional surgeries or complete reversal are indicated [Table 2].
|Table 2: Gastro-esophageal reflux disease related information in published studies|
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Most authors suggest the conversion of OAGB to RYGB as the best procedure,,,,,,,,,, with or without pouch shortening, without biliopancreatic limb length change in the presence of sufficient efferent limb or dismantle the gastrojejunostomy and make a new RYGB with shorter biliopancreatic limb in the presence of short common limb.,,,
An alternative approach may be Braun jejenojejunostomy that there is not any agreement about it. Some authors support Braun jejenojejunostomy,,,,, but others conclude that it is an insufficient method.
Lee et al. suggest the conversion of OAGB to SG or complete reversal to the improvement of persistent GERD symptoms.
It seems that the preoperative symptomatic GERD is a relative contraindication of OAGB.
There are some large series regarding OAGB outcomes [Table 3]. It is obvious that early diagnosis of malnutrition during strict postoperative program and oral supplementation as well as consulting with nutritionist and dietician to improve all nonoperative causes that influence nutritional status. Carbajo et al., and Chevallier et al., did not perform reversal operation for any patient. They report malnutrition in 1.1% (14 cases out of 1200 patients), and 0.2% (2 cases out of 1000 patients) who managed with intravenous (IV) therapy and enteral supplementation. They outlined problems due to deficiency are mostly observed among poor compliant cases. Other authors in larger series performed reversal of OAGB to normal anatomy or conversion to SG. Rutledge and Walsh reported 2410 patients with OAGB, 31 cases (1%) developed excessive weight loss, and all of them underwent revision to a gastroplasty (gastrojejunostomy taking down and gastrogastrostomy essentially reversal of the procedure). Taha et al. reported 3 of 1520 OAGB patients with more than 100% excess weight lost (EWL) treated by revision surgery. Italian experience in OAGB with 2678 patients revealed five case of EWL more than 100%, three of them needed reoperation. Lee et al. also reported 9 of 1322 cases (0.7%) of malnutrition selected for reoperation by different revision strategies. In another 1000 OAGB series reported by Noun et al. four patients (0.4%) affected by excessive weight loss, two of them reversed to normal anatomy, and another two cases converted to SG. Alkhalifah et al.l reported 43 patients (2.5% of overall and 61.4% of total revision) of malnutrition who underwent revision surgery. They did not specify the type of revision surgery, but no patient in this series underwent revision to normal anatomy. Genser et al. reported 26/2934 patients with severe malnutrition, all managed by complete reversal of OAGB and conversion to normal anatomy. When reoperation is indicated for malnutrition, all authors prefer to use again laparoscopic approach with feasible techniques and safe outcome.
One hundred and fifty-three patients underwent reoperations for malnutrition-related complications in 12 studies,,,,,,,,,,, in the long-term follow up of 17938 patients (0.84%).
Weight regain/inadequate weigh loss
Another source of debate is the potential risk OAGB patients have to develop weight regain or inadequate weigh loss in the late period. Previous papers define weight regain as more than 10 Kg, or more than 20% of primary weight. Inadequate weigh loss or weight loss failure considered in patients with ≤25% EBMIL., We did not find the exact period of these definitions in the literature. Some series did not report any patient (s) with regain or inadequate weight loss.,,
Lee et al. reported eight patients (out of total 23 revision surgery) with weigh regain/inadequate weigh loss. The treatment was either duodenal switch or biliopancreatic diversion. In Musella et al., series 11/2678 patients showed weigh loss failure after 5-year follow-up, they revealed that this late onset complication is significantly correlated with a learning curve <50 cases, the performed management was loop resizing in seven, and pouch resizing in four patients.
Nineteen patients (out of 4010) underwent reoperations for weight regain/inadequate weigh loss in two studies, in the long-term.
| Discussion|| |
One of the most important advantages of OAGB/MGB is simplicity of reversal and revision, that makes this procedure safe and more popular. Although there are few conditions need revision or reversal after OAGB, all of them can be resolved after redo surgeries.
The important risk factors of MU can be listed as small gastric pouch, cigarette smoking,,, NSAIDS,, corticosteroids, alcohol, application of nonabsorbable sutures, and learning curve < 50 operations. The nicotine of cigarette is an important factor in MU and perforated ulcer, and it needs to PPIs usage for unlimited period after OAGB in smokers, especially after perforated MU disease. that has comparable incidence with RYGB; if the patient does not respond to first-line medical treatment or complicated MU, revisional surgery is recommended. In this condition, the most popular revisional surgery is conversion to RYGB,,,,,, also there is not any consensus for the procedure of choice for revisional surgery, and resizing the gastric pouch. Some surgeons recommend to avoid performing OAGB in smoker patients due to ulcerogenic effects of nicotine. Furthermore, in a survey on 27,672 patients, RYGB, Reversal, Braun JJ, total gastrectomy, laparoscopic sleeve gastrectomy, and Vagotomy were done for this complication.
Some risk factors of post OAGB GERD are preoperative GERD, revisional OAGB, and short gastric pouch, especially <9 cm.,, Although symptomatic GERD can be a relative contraindication for OAGB, some authors reported significant improvement of GERD after OAGB.,, If GERD is persistent and resistant to optimal medical therapy, revisional surgery must be considered. Maybe the most effective procedure in this sequence is conversional RYGB,,,,,,,,,,,,,, also there are some different methods such as simple jejunojejunostomy and conversion to RYGB by cutting the loop, gastric pouch shortening and re-anastomosis, biliopancreatic, alimentary, and common limb length modifications. There are some controversies about efficacy of Braun's jejunojejunostomy.,,,,,
The malnutrition is a rare and late complication of OAGB. The mechanism of this entity is not clearly defined, but it can cause serious unwanted adverse events, and it will be lethal if leave untreated., Despite main reasons are either jejunal bypass-induced malabsorption or restricted ability to ingest protein-rich foods due to small gastric pouch, however other economic, psychological, social, family, and personal factors also play major roles in developing malnutrition. Clinical manifestations of malnutrition include EWL, anemia, and hypoalbuminemia.
To reduce the rates of malnutrition, we suggest that surgeons should avoid using a bilio-pancreatic limb length of > 150 cm.
We did not find objective and approved definition of excessive weight loss in literature, even in ASMBS, and surgery for obesity and related diseases standard methods for reporting bariatric operation outcomes. However, in Chevallier et al., series of one thousand patients treated by OAGB excessive weight loss defined as more than 100% EWL and serum albumin level <3 g/dl. Another study considered more than 50% EWL along with albumin level <3.5 g/dl and generalized or peripheral edema without response to nutritional support (i.e., oral and IV). Therefore, there is no accepted definition for excessive weight loss based on our search.
The management of weight regain or inadequate weight loss after OAGB mainly is surgical intervention. Duodenal switch, biliopancreatic diversion, pouch resizing, or lengthening the bypassed intestine are reported by various papers.,
| Conclusion|| |
OAGB is now a relatively simple and effective procedure in weight loss surgery and resolution of weight-related comorbidities, with few acceptable complications that can be managed by medical treatment or simple revisional procedures in medical-resistant cases, that surgeons performing OAGB, must be aware these complications and their managements.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Musella M, Susa A, Manno E, De Luca M, Greco F, Raffaelli M, et al
. Complications following the mini/one anastomosis gastric bypass (MGB/OAGB): A multi-institutional survey on 2678 patients with a mid-term (5 years) follow-up. Obes Surg 2017;27:2956-67.
Mahawar KK, Himpens J, Shikora SA, Chevallier JM, Lakdawala M, De Luca M, et al
. The first consensus statement on one anastomosis/mini gastric bypass (OAGB/MGB) using a modified Delphi approach. Obes Surg 2018;28:303-12.
De Luca M, Tie T, Ooi G, Higa K, Himpens J, Carbajo MA, et al
. Mini gastric bypass-one anastomosis gastric bypass (MGB-OAGB)-IFSO position statement. Obes Surg 2018;28:1188-206.
Mahawar KK, Jennings N, Brown J, Gupta A, Balupuri S, Small PK. “Mini” gastric bypass: Systematic review of a controversial procedure. Obes Surg 2013;23:1890-8.
Alkhalifah N, Lee WJ, Hai TC, Ser KH, Chen JC, Wu CC. 15-year experience of laparoscopic single anastomosis (mini-) gastric bypass: Comparison with other bariatric procedures. Surg Endosc 2018;32:3024-31.
Rutledge R, Walsh TR. Continued excellent results with the mini-gastric bypass: Six-year study in 2,410 patients. Obes Surg 2005;15:1304-8.
Rutledge R, Kular K, Manchanda N. The mini-gastric bypass original technique. Int J Surg 2019;61:38-41.
Mahawar KK, Kumar P, Carr WR, Jennings N, Schroeder N, Balupuri S, et al
. Current status of mini-gastric bypass. J Minim Access Surg 2016;12:305-10.
Apers J, Wijkmans R, Totte E, Emous M. Implementation of mini gastric bypass in the Netherlands: Early and midterm results from a high-volume unit. Surg Endosc 2018;32:3949-55.
Bruzzi M, Rau C, Voron T, Guenzi M, Berger A, Chevallier JM. Single anastomosis or mini-gastric bypass: Long-term results and quality of life after a 5-year follow-up. Surg Obes Relat Dis 2015;11:321-6.
Lee WJ, Lee YC, Ser KH, Chen SC, Chen JC, Su YH. Revisional surgery for laparoscopic minigastric bypass. Surg Obes Relat Dis 2011;7:486-91.
Chevallier JM, Arman GA, Guenzi M, Rau C, Bruzzi M, Beaupel N, et al
. One thousand single anastomosis (omega loop) gastric bypasses to treat morbid obesity in a 7-year period: Outcomes show few complications and good efficacy. Obes Surg 2015;25:951-8.
Carbajo MA, Luque-de-León E, Jiménez JM, Ortiz-de-Solórzano J, Pérez-Miranda M, Castro-Alija MJ. Laparoscopic one-anastomosis gastric bypass: Technique, results, and long-term follow-up in 1200 patients. Obes Surg 2017;27:1153-67.
Taha O, Abdelaal M, Abozeid M, Askalany A, Alaa M. Outcomes of omega loop gastric bypass, 6-years experience of 1520 cases. Obes Surg 2017;27:1952-60.
Noun R, Skaff J, Riachi E, Daher R, Antoun NA, Nasr M. One thousand consecutive mini-gastric bypass: Short- and long-term outcome. Obes Surg 2012;22:697-703.
Genser L, Soprani A, Tabbara M, Siksik JM, Cady J, Carandina S. Laparoscopic reversal of mini-gastric bypass to original anatomy for severe postoperative malnutrition. Langenbecks Arch Surg 2017;402:1263-70.
Chen CY, Lee WJ, Lee HM, Chen JC, Ser KH, Lee YC, et al
. Laparoscopic conversion of gastric bypass complication to sleeve gastrectomy: Technique and early results. Obes Surg 2016;26:2014-21.
Seetharamaiah S, Tantia O, Goyal G, Chaudhuri T, Khanna S, Singh JP, et al
. LSG vs OAGB–1 year follow-up data – A randomized control trial. Obes Surg 2017;27:948-54.
Mahawar KK, Reed AN, Graham YN. Marginal ulcers after one anastomosis (mini) gastric bypass: A survey of surgeons. Clin Obes 2017;7:151-6.
Johnson WH, Fernanadez AZ, Farrell TM, Macdonald KG, Grant JP, McMahon RL, et al
. Surgical revision of loop (”mini”) gastric bypass procedure: Multicenter review of complications and conversions to Roux-en-Y gastric bypass. Surg Obes Relat Dis 2007;3:37-41.
Rutledge R. The mini-gastric bypass: Experience with the first 1,274 cases. Obes Surg 2001;11:276-80.
Mahawar KK, Borg CM, Kular KS, Courtney MJ, Sillah K, Carr WR, et al
. Understanding objections to one anastomosis (mini) gastric bypass: A survey of 417 surgeons not performing this procedure. Obes Surg 2017;27:2222-8.
Coblijn UK, Lagarde SM, de Castro SM, Kuiken SD, van Wagensveld BA. Symptomatic marginal ulcer disease after roux-en-Y gastric bypass: Incidence, risk factors and management. Obes Surg 2015;25:805-11.
Hussain A, El-Hasani S. Short-and mid-term outcomes of 527 one anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) operations: Retrospective study. Obes Surg 2019;29:262-7.
Bolckmans R, Arman G, Himpens J. Efficiency and risks of laparoscopic conversion of omega anastomosis gastric bypass to Roux-en-Y gastric bypass. Surg Endosc 2019;33:2572-82.
Nimeri A, Maasher A, Al Shaban T. Efferent limb obstruction and unexpected perforated marginal ulcer in a pregnant patient after one anastomosis gastric bypass/mini gastric bypass. Surg Obes Relat Dis 2017;13:713-5.
Godina M, Nagliati C, Menegon P, Caruso V. Emergency laparoscopic conversion from mini/one anastomosis gastric bypass to modified roux-en-Y-gastric bypass due to acute bleeding from a recurrent marginal ulcer. Updates Surg 2017;69:421-4.
Tolone S, Cristiano S, Savarino E, Lucido FS, Fico DI, Docimo L. Effects of omega-loop bypass on esophagogastric junction function. Surg Obes Relat Dis 2016;12:62-9.
Piazza L, Ferrara F, Leanza S, Coco D, Sarvà S, Bellia A, et al
. Laparoscopic mini-gastric bypass: Short-term single-institute experience. Updates Surg 2011;63:239-42.
Musella M, Susa A, Greco F, De Luca M, Manno E, Di Stefano C, et al
. The laparoscopic mini-gastric bypass: The Italian experience: Outcomes from 974 consecutive cases in a multicenter review. Surg Endosc 2014;28:156-63.
Shenouda MM, Harb SE, Mikhail SA, Mokhtar SM, Osman AM, Wassef AT, et al
. Bile gastritis following laparoscopic single anastomosis gastric bypass: Pilot study to assess significance of bilirubin level in gastric aspirate. Obes Surg 2018;28:389-95.
Carbajo M, García-Caballero M, Toledano M, Osorio D, García-Lanza C, Carmona JA. One-anastomosis gastric bypass by laparoscopy: Results of the first 209 patients. Obes Surg 2005;15:398-404.
Bruzzi M, Chevallier JM, Czernichow S. One-anastomosis gastric bypass: Why biliary reflux remains controversial? Obes Surg 2017;27:545-7.
Facchiano E, Leuratti L, Veltri M, Lucchese M. Laparoscopic conversion of one anastomosis gastric bypass to roux-en-y gastric bypass for chronic bile reflux. Obes Surg 2016;26:701-3.
Saarinen T, Räsänen J, Salo J, Loimaala A, Pitkonen M, Leivonen M, et al
. Bile reflux scintigraphy after mini-gastric bypass. Obes Surg 2017;27:2083-9.
Amor IB, Petrucciani N, Kassir R, Al Munifi A, Piche T, Debs T, et al
. Laparoscopic conversion of one anastomosis gastric bypass to a standard roux-en-Y gastric bypass. Obes Surg 2017;27:1398.
Nimeri A, Al Shaban T, Maasher A. Laparoscopic conversion of one anastomosis gastric bypass/mini gastric bypass to roux-en-Y gastric bypass for bile reflux gastritis. Surg Obes Relat Dis 2017;13:119-21.
Bal BS, Finelli FC, Shope TR, Koch TR. Nutritional deficiencies after bariatric surgery. Nat Rev Endocrinol 2012;8:544-56.
Ledoux S, Calabrese D, Bogard C, Dupré T, Castel B, Msika S, et al
. Long-term evolution of nutritional deficiencies after gastric bypass: An assessment according to compliance to medical care. Ann Surg 2014;259:1104-10.
Moon RC, Frommelt A, Teixeira AF, Jawad MA. Indications and outcomes of reversal of roux-en-Y gastric bypass. Surg Obes Relat Dis 2015;11:821-6.
Boyle M, Mahawar K. One Anastomosis Gastric Bypass Performed with a 150-cm Biliopancreatic Limb Delivers Weight Loss Outcomes Similar to Those with a 200-cm Biliopancreatic Limb at 18 -24 Months [published online ahead of print, 2019 Dec 16]. Obes Surg. 2019;10.1007/s11695-019-04359-5. doi:10.1007/s11695-019-04359-5.
Brethauer SA, Kim J, El Chaar M, Papasavas P, Eisenberg D, Rogers A, et al
. Standardized outcomes reporting in metabolic and bariatric surgery. Obes Surg 2015;25:587-606.
[Table 1], [Table 2], [Table 3]