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Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property
Won Sriwijitalai1, Viroj Wiwanitkit2
1 Private Academic Writer/Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China; Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria
| Date of Submission | 28-Mar-2020 |
| Date of Decision | 04-Apr-2020 |
| Date of Acceptance | 15-Apr-2020 |
| Date of Web Publication | 06-May-2020 |
Correspondence Address:
Dr. Won Sriwijitalai
RVT Medical Center, Bangkok
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jrms.JRMS_312_20
How to cite this article:
Sriwijitalai W, Wiwanitkit V. Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property. J Res Med Sci 2020;25:44 |
How to cite this URL:
Sriwijitalai W, Wiwanitkit V. Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property. J Res Med Sci [serial online] 2020 [cited 2021 Apr 14];25:44. Available from: https://www.jmsjournal.net/text.asp?2020/25/1/44/283851 |
COVID-19 is an important new infectious disease that affects >150 countries worldwide. This respiratory infection is a public health emergency to be managed. As a new disease, there is limited knowledge of treatment. In general, many drugs are tests for possible efficacy in disease management. The widely used antiviral drugs include oseltamivir and anti-HIV drugs.[1] In medical science, there are also attempts to find herbs, natural products, which might be effective in the treatment of the coronavirus disease.[2] In the previous report, an important target that is useful for the treatment of coronavirus disease is tyrosine kinase.[3] Any herbs that pose anti-tyrosine kinase property might be useful for the treatment of COVID-19. Here, the authors perform a pharmacoinformatics study to search for herbs that have antipeptidase property and might be useful. Using the same database mining technique as in the referencing publication,[4] the PubMed database is used as a primary tool for data mining. According to data mining, there are at least herbs that present anti-tyrosine kinase properties and might be useful for the treatment of COVID-19. Those herbs are Hesperethusa crenulata,[5]Perilla frutescens,[6]Ephedra equisetina,[7]Shiraia bambusicola,[8]Panax ginseng[9] and Carthamus tinctorius L [Table 1].[10] Of interest, those herbs are the classical well-known herbs in East Asia, where the COVID-19first emerged. The present data mining is only to roughly include potential herbs for further studies on the possible usefulness in the management of COVID-19. Some of these herbs are already confirmed for their advantages in the management of viral respiratory infections. For example, E. equisetina and P. ginseng are confirmed for its anti-influenza property.[11],[12] | Table 1: Local herbs that have potentials for the treatment of coronavirus disease 2019
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Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther 2020;14:58-60.  |
| 2. | Ling CQ. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). J Integr Med 2020;18:87-8. |
| 3. | Sisk JM, Frieman MB, Machamer CE. Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors. J Gen Virol 2018;99:619-30. |
| 4. | Wiwanitkit V. Analysis of Mycobacterium leprae genome: In silico searching for drug targets. Southeast Asian J Trop Med Public Health 2005;36 Suppl 4:225-7. |
| 5. | Wangthong S, Palaga T, Rengpipat S, Wanichwecharungruang SP, Chanchaisak P, Heinrich M. Biological activities and safety of Thanaka ( Hesperethusa crenulata) stem bark. J Ethnopharmacol 2010;132:466-72. |
| 6. | El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, et al. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology 2018;70:913-9. |
| 7. | Hyuga S. The pharmacological actions of ephedrine alkaloids-free ephreda herb extract and preparation for clinical application. Yakugaku Zasshi 2017;137:179-86. |
| 8. | Zhang YX, Chen Y, Guo XN, Zhang XW, Zhao WM, Zhong L, et al. 11,11'-dideoxy-verticillin: A natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity. Anticancer Drugs 2005;16:515-24. |
| 9. | Sathishkumar N, Karpagam V, Sathiyamoorthy S, Woo MJ, Kim YJ, Yang DC. Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng. Comput Biol Med 2013;43:786-97. |
| 10. | Yuk TH, Kang JH, Lee SR, Yuk SW, Lee KG, Song BY, et al. Inhibitory effect of Carthamus tinctorius L. seed extracts on bone resorption mediated by tyrosine kinase, COX-2 (cyclooxygenase) and PG (prostaglandin) E2. Am J Chin Med 2002;30:95-108. |
| 11. | Hyuga S, Hyuga M, Oshima N, Maruyama T, Kamakura H, Yamashita T, et al. Ephedrine alkaloids-free ephedra herb extract: A safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities. J Nat Med 2016;70:571-83. |
| 12. | Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]. Drugs Exp Clin Res 1996;22:65-72. |
[Table 1]
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