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J Res Med Sci 2020,  25:44

Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property

1 Private Academic Writer/Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China; Department of Biological Science, Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria

Date of Submission28-Mar-2020
Date of Decision04-Apr-2020
Date of Acceptance15-Apr-2020
Date of Web Publication06-May-2020

Correspondence Address:
Dr. Won Sriwijitalai
RVT Medical Center, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrms.JRMS_312_20

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How to cite this article:
Sriwijitalai W, Wiwanitkit V. Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property. J Res Med Sci 2020;25:44

How to cite this URL:
Sriwijitalai W, Wiwanitkit V. Herbs that might be effective for the management of COVID-19: A bioinformatics analysis on anti-tyrosine kinase property. J Res Med Sci [serial online] 2020 [cited 2022 Nov 28];25:44. Available from: https://www.jmsjournal.net/text.asp?2020/25/1/44/283851

COVID-19 is an important new infectious disease that affects >150 countries worldwide. This respiratory infection is a public health emergency to be managed. As a new disease, there is limited knowledge of treatment. In general, many drugs are tests for possible efficacy in disease management. The widely used antiviral drugs include oseltamivir and anti-HIV drugs.[1] In medical science, there are also attempts to find herbs, natural products, which might be effective in the treatment of the coronavirus disease.[2] In the previous report, an important target that is useful for the treatment of coronavirus disease is tyrosine kinase.[3] Any herbs that pose anti-tyrosine kinase property might be useful for the treatment of COVID-19. Here, the authors perform a pharmacoinformatics study to search for herbs that have antipeptidase property and might be useful. Using the same database mining technique as in the referencing publication,[4] the PubMed database is used as a primary tool for data mining. According to data mining, there are at least herbs that present anti-tyrosine kinase properties and might be useful for the treatment of COVID-19. Those herbs are Hesperethusa crenulata,[5]Perilla frutescens,[6]Ephedra equisetina,[7]Shiraia bambusicola,[8]Panax ginseng[9] and Carthamus tinctorius L [Table 1].[10] Of interest, those herbs are the classical well-known herbs in East Asia, where the COVID-19first emerged. The present data mining is only to roughly include potential herbs for further studies on the possible usefulness in the management of COVID-19. Some of these herbs are already confirmed for their advantages in the management of viral respiratory infections. For example, E. equisetina and P. ginseng are confirmed for its anti-influenza property.[11],[12]
Table 1: Local herbs that have potentials for the treatment of coronavirus disease 2019

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There are no conflicts of interest.

  References Top

Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther 2020;14:58-60.  Back to cited text no. 1
Ling CQ. Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2). J Integr Med 2020;18:87-8.  Back to cited text no. 2
Sisk JM, Frieman MB, Machamer CE. Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors. J Gen Virol 2018;99:619-30.  Back to cited text no. 3
Wiwanitkit V. Analysis of Mycobacterium leprae genome: In silico searching for drug targets. Southeast Asian J Trop Med Public Health 2005;36 Suppl 4:225-7.  Back to cited text no. 4
Wangthong S, Palaga T, Rengpipat S, Wanichwecharungruang SP, Chanchaisak P, Heinrich M. Biological activities and safety of Thanaka (Hesperethusa crenulata) stem bark. J Ethnopharmacol 2010;132:466-72.  Back to cited text no. 5
El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, et al. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology 2018;70:913-9.  Back to cited text no. 6
Hyuga S. The pharmacological actions of ephedrine alkaloids-free ephreda herb extract and preparation for clinical application. Yakugaku Zasshi 2017;137:179-86.  Back to cited text no. 7
Zhang YX, Chen Y, Guo XN, Zhang XW, Zhao WM, Zhong L, et al. 11,11'-dideoxy-verticillin: A natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity. Anticancer Drugs 2005;16:515-24.  Back to cited text no. 8
Sathishkumar N, Karpagam V, Sathiyamoorthy S, Woo MJ, Kim YJ, Yang DC. Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng. Comput Biol Med 2013;43:786-97.  Back to cited text no. 9
Yuk TH, Kang JH, Lee SR, Yuk SW, Lee KG, Song BY, et al. Inhibitory effect of Carthamus tinctorius L. seed extracts on bone resorption mediated by tyrosine kinase, COX-2 (cyclooxygenase) and PG (prostaglandin) E2. Am J Chin Med 2002;30:95-108.  Back to cited text no. 10
Hyuga S, Hyuga M, Oshima N, Maruyama T, Kamakura H, Yamashita T, et al. Ephedrine alkaloids-free ephedra herb extract: A safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities. J Nat Med 2016;70:571-83.  Back to cited text no. 11
Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardised Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]. Drugs Exp Clin Res 1996;22:65-72.  Back to cited text no. 12


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