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LETTER TO EDITOR
J Res Med Sci 2020,  25:33

Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation


1 Medical Academic Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission11-Feb-2020
Date of Decision15-Mar-2020
Date of Acceptance16-Mar-2020
Date of Web Publication30-Mar-2020

Correspondence Address:
Dr. Beuy Joob
Medical Academic Center, Bangkok, Thailand
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_147_20

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How to cite this article:
Joob B, Wiwanitkit V. Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation. J Res Med Sci 2020;25:33

How to cite this URL:
Joob B, Wiwanitkit V. Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation. J Res Med Sci [serial online] 2020 [cited 2020 Oct 24];25:33. Available from: https://www.jmsjournal.net/text.asp?2020/25/1/33/281623



Dear Editor,

Wuhan coronavirus infection is the new emerging coronavirus infection caused by the 2019 novel coronavirus (2019 n-CoV).[1] The 2019 n-CoV wasfirstly isolated, sequenced, and recorded from China. After thefirst discovery of 2019 n-CoV infection, more cases are observed in China as well as in other countries.[2] The disease was detected and molecularly confirmed in several countries (such as the USA and Australia). The accelerating increased number of infected cases[3] leads to the WHO declaration on global emergence regarding this new disease.

Here, the authors performed comparative genomics analysis on public available complete genomes of 2019 n-CoV recorded in the 1st month of outbreak (December 2019–January 2020). Overall, ten available complete genomes in PubMed were processed by BLAST tool for multiple alignments (https://blast.ncbi.nlm.nih.gov/BlastAlign.cgi). The studied genomes include MN988668.1 (thefirst referencing genome), MN997409.1, MN988669.1, MN994468.1, MN994467.1, MN985325.1, MN988713.1, MN975262.1, MN938384.1, and MT007544.1. According to the analysis, the similarity ranges from 99.96% to 100% (average = 99.983% +0.012%). The variation, which implies mutation, is 0%–0.04% within the 1st month period of outbreak. Therefore, the mutation of the new 2019 n-CoV already occurs. Further monitoring on progress of mutation is recommended for early detection of possible emerging serious variant of the virus.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Hsia W. Emerging new coronavirus infection in Wuhan, China: Situation in early 2020. Case Study Case Rep 2020;10:8-9.  Back to cited text no. 1
    
2.
Yasri S, Wiwanitkit V. Editorial: Wuhan coronavirus outbreak and imported case. Adv Trop Med Pub Health Int 2020;10:1-2.  Back to cited text no. 2
    
3.
Sookaromdee P, Wiwanitkit V. Imported cases of 2019-novel coronavirus (2019-nCoV) infections in Thailand: Mathematical modelling of the outbreak.Asian Pac J Trop Med 2020;13:139-40asp?id=277516. [Last accessed on 2020 Feb 04].  Back to cited text no. 3
    



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[Pubmed] | [DOI]



 

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