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J Res Med Sci 2020,  25:30

The effects of cobalamin and B-complex on hypermenorrhea

Department of Gynaecology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Date of Web Publication20-Jan-2020

Correspondence Address:
Dr. Shiva Hadadianpour
N04, Ramezani Street, Poonak Sq, Tehran
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrms.JRMS_862_18

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How to cite this article:
Yassaee F, Hadadianpour S. The effects of cobalamin and B-complex on hypermenorrhea. J Res Med Sci 2020;25:30

How to cite this URL:
Yassaee F, Hadadianpour S. The effects of cobalamin and B-complex on hypermenorrhea. J Res Med Sci [serial online] 2020 [cited 2023 Jun 5];25:30. Available from: https://www.jmsjournal.net/text.asp?2020/25/1/30/280932


As gynecologists, we were surprised to see the great effect of B-12 and B-complex on hypermenorrhea. We found it accidentally while trying to deal with the anemia symptoms of hypermenorrhea.

During the time the patients with prolonged bleeding (bleeding more than 10 days) were waiting for laboratory and imaging results, we prescribed one B-complex and one B-12 ampule,[1] daily for 5 days, to these patients who showed no underlying diseases in order to relieve the weakness and dizziness resulting from anemia. We surprisingly noticed that their irregular bleeding stopped. (The hypermenorrhea of 43 out of 47 patients responded favorably to this treatment). Then, we followed them up for two more cycles and we found that the bleeding pattern was normal.

Then, we decided to explore related articles to find a justification. After searching the articles, we came across one article in Women's Encyclopedia of Natural Medicine which had dealt with the effect of B-complex deficiency on estrogen metabolism and menstruation,[2] and another study about the effect of supplementation with vitamin B-complex on estrogen level that was published in the International Journal for Vitamin and Nutrition Research.[3] They both suggested that Vitamin B12 and B-complex cause an increase in estrogen level, which leads to endometrial proliferation. Prolonged bleeding decreases the thickness of endometrium in hypermenorrhic women and causes irregular bleeding, so these two vitamins play treatment roles.

Hereby, we would like to announce that B-complex and B-12 can serve a vital role in treating hypermenorrhic cases. We also call for further clinical trials with project and ethical number to explore in more details the effects of B-12 and B-complex on hypermenorrhea and their appropriate therapeutic doses.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr 2000;3:125-50.  Back to cited text no. 1
Livdans-Forret AB, Harvey PJ, Larkin-Thier SM. Menorrhagia: A synopsis of management focusing on herbal and nutritional supplements, and chiropractic. J Can Chiropr Assoc 2007;51:235-46.  Back to cited text no. 2
Palmas W. Effects of short-term supplementation with ascorbate, folate, and Vitamins B6 and B12 on inflammatory factors and estrogen levels in obese postmenopausal women. Int J Vitam Nutr Res 2006;76:34-8.  Back to cited text no. 3


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