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Risk factors of the efficacy of hepatitis B vaccine in health-care workers
Hassan Salehi1, Marzieh Salehi2, Nader Kalbasi3, Maryam Salehi4, Jalil Sharifian5, Mohammad Mahdi Salehi4
1 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Infectious Diseases, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Oral and Facial Pathology, Dentistry Faculty, Khoraskan University, Isfahan, Iran
4 Dentistry Student Research Center, Dentistry School, Isfahan University of Medical Sciences, Isfahan, Iran
5 Oral Surgery Department, Dentistry School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Correspondence Address:
Dr. Mohammad Mahdi Salehi
Student Research Center, Dentistry School, Isfahan University of Medical Sciences, Isfahan
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jrms.JRMS_1054_18
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Background: Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%–10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers. Materials and Methods: This was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study. Results: Age (> 40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors. Conclusion: In the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.
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