Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Jiaming Cui; Wei Lu; Yong He; Luoyong Jiang; Kuokuo Li; Weimin Zhu; Daping Wang

doi:10.4103/jrms.JRMS_1005_16

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Year : 2017 | Volume : 22 | Issue : 1 | Page : 61

Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Jiaming Cui¹, Wei Lu², Yong He³, Luoyong Jiang³, Kuokuo Li³, Weimin Zhu¹, Daping Wang¹
¹ Guangzhou Medical University, Guangzhou 510182; Department of Sports Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University; Shenzhen Research and Development Engineering Center for Sports Medicine, Shenzhen 518000; Chinese Orthopaedic Regenerative Medicine Group, Hangzhou 310000, P. R. China
² Department of Sports Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University; Shenzhen Research and Development Engineering Center for Sports Medicine, Shenzhen 518000; Chinese Orthopaedic Regenerative Medicine Group, Hangzhou 310000, P. R. China
³ Department of Sports Medicine, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518000, P. R. China

Correspondence Address:
Daping Wang
Department of Sports Medical, Shenzhen Second People Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, P. R. China. No. 3002, Sungang West Road, Shenzhen, Guangdong 518000
P. R. China
Weimin Zhu
Department of Sports Medical, Shenzhen Second People Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, P. R. China. No. 3002, Sungang West Road, Shenzhen, Guangdong 518000
P. R. China

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jrms.JRMS_1005_16

Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of literature on the molecular biology of frozen shoulder, and the molecular biological mechanism for periarthritis-induced limitation of shoulder joint movements remains unclear. Research in this field is focused on inflammation and cytokines associated with fibrosis. Repeated investigations confirmed alterations of specified inflammatory mediators and fibrosis-associated cytokines, which might be involved in the pathogenesis of frozen shoulder by causing structural changes of the shoulder joint and eventually the limitation of shoulder movements. The aim of this article is to review studies on molecular biology of frozen shoulder and provide a reference for subsequent research, treatment, and development of new drugs.

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