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  Indian J Med Microbiol
 

Figure 2: Histological changes in rats with choline-deficient diet - induced nonalcoholic fatty liver disease: (a) Normal group (sham): Liver sinusoid and hepatocytes are normal. (b) Vehicle-treated group: Severe vacuolar degeneration and hepatocyte swelling are observable. (c) Positive control: Some sinusoids are swelled but cellular damage is repaired in comparison to vehicle-treated animals. (d) Pimpinella anisum extract 200 mg/kg: Macrovesicular steatohepatitis is decreased and the microscopic view is similar to sham. (e) Pimpinella anisum extract 100 mg/kg: Some hepatocytes are swelled but no necrosis is observable. (f) Pimpinella anisum essential oil 0.5 mg/kg: Vacuolar degeneration is remarkably decreased in comparison to vehicle-treated group

Figure 2: Histological changes in rats with choline-deficient diet - induced nonalcoholic fatty liver disease: (a) Normal group (sham): Liver sinusoid and hepatocytes are normal. (b) Vehicle-treated group: Severe vacuolar degeneration and hepatocyte swelling are observable. (c) Positive control: Some sinusoids are swelled but cellular damage is repaired in comparison to vehicle-treated animals. (d) <i>Pimpinella anisum</i> extract 200 mg/kg: Macrovesicular steatohepatitis is decreased and the microscopic view is similar to sham. (e) <i>Pimpinella anisum</i> extract 100 mg/kg: Some hepatocytes are swelled but no necrosis is observable. (f)<i> Pimpinella anisum</i> essential oil 0.5 mg/kg: Vacuolar degeneration is remarkably decreased in comparison to vehicle-treated group