Journal of Research in Medical Sciences

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 25  |  Issue : 1  |  Page : 29-

Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy


Marjan Oustad1, Mohamadreza Najafi1, Jafar Mehvari1, Amin Rastgoo2, Zahrasadat Mortazavi1, Mitra Rahiminejad1 
1 Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
2 Neurosurgeon, Imam Khomeini Hospital, Kangan, Bushehr University of Medical Sciences, Bushehr, Iran

Correspondence Address:
Dr. Mohamadreza Najafi
Department of Neurology, Al.Zahra Hospital, Isfahan
Iran

Background: Cognitive impairment is a common complication of patients with temporal lobe epilepsy (TLE). Therefore, the aim of this study was to compare the effects of donepezil and memantine on improving the cognitive function of patients with TLE. Materials and Methods: In a clinical trial study, 70 patients with TLE were divided into two groups of 35 each: 10 mg doses of donepezil ( first group) and memantine (second group) were applied for 16 weeks. The level of cognitive function of patients in both groups before and after treatment was determined using Montreal Cognitive Assessment (MoCA) test. Results: The mean score of MoCA before and after intervention was 23.55 ± 3.67 and 26.09 ± 2.5, respectively, in the group treated with memantine, and the mean score of intervention was significantly improved (P < 0.001). In the group treated with donepezil, the score before and after the operation was 23.87 ± 3.18 and 24.35 ± 2.17, respectively, and no significant difference was observed in this group (P = 0.38). Conclusion: Hence, memantine was better than donepezil in the improvement of cognitive impairment in patients with TLE.


How to cite this article:
Oustad M, Najafi M, Mehvari J, Rastgoo A, Mortazavi Z, Rahiminejad M. Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy.J Res Med Sci 2020;25:29-29


How to cite this URL:
Oustad M, Najafi M, Mehvari J, Rastgoo A, Mortazavi Z, Rahiminejad M. Effect of donepezil and memantine on improvement of cognitive function in patients with temporal lobe epilepsy. J Res Med Sci [serial online] 2020 [cited 2020 Jul 14 ];25:29-29
Available from: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=29;epage=29;aulast=Oustad;type=0