Journal of Research in Medical Sciences

REVIEW ARTICLE
Year
: 2018  |  Volume : 23  |  Issue : 1  |  Page : 75-

Vitamin D, the gut microbiome and inflammatory bowel disease


Seyed-Amir Tabatabaeizadeh1, Niayesh Tafazoli3, Gordon A Ferns2, Amir Avan3, Majid Ghayour-Mobarhan3 
1 Department of Nutrition, Faculty of Medicine; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
2 Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
3 Metabolic Syndrome Research Center; Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Dr. Amir Avan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad
Iran
Prof. Majid Ghayour-Mobarhan
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad
Iran

Vitamin D has an important role in bone metabolism but recently has been recognized as an immunoregulator, and this has led to investigations on the effect of Vitamin D supplementation in various autoimmune diseases and its anti-inflammatory effects. There is some evidence that Vitamin D can regulate gastrointestinal inflammation. In addition, previous studies have shown that Vitamin D can affect the gut microbiome. The aim of this review is to evaluate the effect of Vitamin D on inflammatory processes, especially its relation to the inflammatory bowel disease (IBD) and gut microbiome. There is some evidence that Vitamin D can regulate gastrointestinal inflammation, with epidemiological studies showing that individuals with higher serum Vitamin D have a lower incidence of IBD, particularly Crohn's disease. Vitamin D changes transcription of cathelicidin and DEFB4 (defensin, beta 4) that can affect the gut microbiome. Several cell types of the immune system express Vitamin D receptor, and hence the use of Vitamin D in immune regulation has some potential. Furthermore, Vitamin D deficiency leads to dysbiosis of gut microbiome and reported to cause severe colitis. Vitamin D supplementation is low cost and available and can be a therapeutic option.


How to cite this article:
Tabatabaeizadeh SA, Tafazoli N, Ferns GA, Avan A, Ghayour-Mobarhan M. Vitamin D, the gut microbiome and inflammatory bowel disease.J Res Med Sci 2018;23:75-75


How to cite this URL:
Tabatabaeizadeh SA, Tafazoli N, Ferns GA, Avan A, Ghayour-Mobarhan M. Vitamin D, the gut microbiome and inflammatory bowel disease. J Res Med Sci [serial online] 2018 [cited 2019 Jun 16 ];23:75-75
Available from: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=75;epage=75;aulast=Tabatabaeizadeh;type=0