Journal of Research in Medical Sciences

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 23  |  Issue : 1  |  Page : 71-

Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices


Marwan S M Al-Nimer1, Talar A Merza Mohammad2, Riyadh A Alsakeni3 
1 Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil; Department of Clinical Pharmacology and Therapeutics, Al-Mustansiriya University, Baghdad, Iraq
2 Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil, Iraq
3 Department of Medicine, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq

Correspondence Address:
Prof. Marwan S M Al-Nimer
Department of Pharmacology and Toxicology, College of Pharmacy, Hawler Medical University, Erbil
Iraq

Background: This study aimed to assess the serum serotonin levels in the newly diagnosed fibromyalgia (FM) and to relate these levels to the presenting signs and symptoms. Materials and Methods: This case–control study included 35 healthy women (Group I) served as controls and 130 women with newly diagnosed FM (Group II). The diagnosis of FM was confirmed by the diagnostic criteria of the American College of Rheumatology-10. The assessment of pain using a revised fibromyalgia impact questionnaire and tender points scoring, blood platelet indices, and serum serotonin levels were determined. Results: Group II patients had significantly (P < 0.001) higher values of mean platelet volume (MPV) (10.60 ± 1.57fL) and platelet width distribution (16.25 ± 1.45%) than the corresponding values in Group I (8.73 ± 0.81fL and 15.0 ± 1.15%). Significant low-serum serotonin levels observed in Group II patients compared with Group I healthy individuals (187.3 ± 50.3 ng/ml vs. 219.5 ± 78.3 ng/ml, P = 0.026). Multiple linear regression analysis showed the nonsignificant correlations between serum serotonin levels and platelet indices in Group II patients. Conclusion: Newly diagnosed FM women have significantly low-serum serotonin levels, which does not correlate with a significant increment of the platelet activity expressed as increase MPV and platelet width distribution percentage. Therefore, this study highlighted that the correction of serum serotonin level by medicines could help the patients.


How to cite this article:
Al-Nimer MS, Mohammad TA, Alsakeni RA. Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices.J Res Med Sci 2018;23:71-71


How to cite this URL:
Al-Nimer MS, Mohammad TA, Alsakeni RA. Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices. J Res Med Sci [serial online] 2018 [cited 2019 Jul 22 ];23:71-71
Available from: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=71;epage=71;aulast=Al-Nimer;type=0