Journal of Research in Medical Sciences

REVIEW ARTICLE
Year
: 2018  |  Volume : 23  |  Issue : 1  |  Page : 51-

Is aluminum exposure a risk factor for neurological disorders?


Elif Inan-Eroglu, Aylin Ayaz 
 Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey

Correspondence Address:
Dr. Aylin Ayaz
Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100
Turkey

Aluminum (Al) is widely found in the nature. Although the relation between Al and neurodegenerative diseases is still controversial, Al is related with many brain diseases including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Al exposure occurs mainly through environment, occupational, and dietary factors for humans. Al exposure with diet can be through foods, food additives, water, and contamination of Al equipment/utensils. The aim of this review is to summarize various hypotheses, which link Al and neurodegeneration, and to determine the roles of Al exposure through different sources including diet, environment, and occupation. Future studies should be done in vulnerable subgroups of population including children, patients receiving antacid or Al-containing pharmeteucials on a daily basis, patients with reduced renal function, and patients on parenteral nutrition regimens that are likely to be affected by possible adverse health effects of Al. In addition, gender, age, and Al interactions need to be determined. One of the most important challanges in future epidemiological studies is to determine which variables should be controlled. In addition, experimental studies should be more focused and translational. In this context, exposure dose, dose–response effects, and time lapse between exposures and cognitive assessments are very important.


How to cite this article:
Inan-Eroglu E, Ayaz A. Is aluminum exposure a risk factor for neurological disorders?.J Res Med Sci 2018;23:51-51


How to cite this URL:
Inan-Eroglu E, Ayaz A. Is aluminum exposure a risk factor for neurological disorders?. J Res Med Sci [serial online] 2018 [cited 2019 Jul 17 ];23:51-51
Available from: http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2018;volume=23;issue=1;spage=51;epage=51;aulast=Inan-Eroglu;type=0