Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation
Beuy Joob1, Viroj Wiwanitkit2
1 Medical Academic Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India
|Date of Submission||11-Feb-2020|
|Date of Decision||15-Mar-2020|
|Date of Acceptance||16-Mar-2020|
|Date of Web Publication||30-Mar-2020|
Dr. Beuy Joob
Medical Academic Center, Bangkok, Thailand
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Joob B, Wiwanitkit V. Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation. J Res Med Sci 2020;25:33
|How to cite this URL:|
Joob B, Wiwanitkit V. Variation of 2019 novel coronavirus complete genomes recorded in the 1st month of outbreak: Implication for mutation. J Res Med Sci [serial online] 2020 [cited 2020 Sep 19];25:33. Available from: http://www.jmsjournal.net/text.asp?2020/25/1/33/281623
Wuhan coronavirus infection is the new emerging coronavirus infection caused by the 2019 novel coronavirus (2019 n-CoV). The 2019 n-CoV wasfirstly isolated, sequenced, and recorded from China. After thefirst discovery of 2019 n-CoV infection, more cases are observed in China as well as in other countries. The disease was detected and molecularly confirmed in several countries (such as the USA and Australia). The accelerating increased number of infected cases leads to the WHO declaration on global emergence regarding this new disease.
Here, the authors performed comparative genomics analysis on public available complete genomes of 2019 n-CoV recorded in the 1st month of outbreak (December 2019–January 2020). Overall, ten available complete genomes in PubMed were processed by BLAST tool for multiple alignments (https://blast.ncbi.nlm.nih.gov/BlastAlign.cgi). The studied genomes include MN988668.1 (thefirst referencing genome), MN997409.1, MN988669.1, MN994468.1, MN994467.1, MN985325.1, MN988713.1, MN975262.1, MN938384.1, and MT007544.1. According to the analysis, the similarity ranges from 99.96% to 100% (average = 99.983% +0.012%). The variation, which implies mutation, is 0%–0.04% within the 1st month period of outbreak. Therefore, the mutation of the new 2019 n-CoV already occurs. Further monitoring on progress of mutation is recommended for early detection of possible emerging serious variant of the virus.
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Conflicts of interest
There are no conflicts of interest.
| References|| |
Hsia W. Emerging new coronavirus infection in Wuhan, China: Situation in early 2020. Case Study Case Rep 2020;10:8-9.
Yasri S, Wiwanitkit V. Editorial: Wuhan coronavirus outbreak and imported case. Adv Trop Med Pub Health Int 2020;10:1-2.
Sookaromdee P, Wiwanitkit V. Imported cases of 2019-novel coronavirus (2019-nCoV) infections in Thailand: Mathematical modelling of the outbreak.Asian Pac J Trop Med 2020;13:139-40asp?id=277516. [Last accessed on 2020 Feb 04].