Home About us Editorial board Ahead of print Browse Articles Search Submit article Instructions Subscribe Contacts Login 
  • Users Online: 302
  • Home
  • Print this page
  • Email this page
SHORT COMMUNICATION
Year : 2018  |  Volume : 23  |  Issue : 1  |  Page : 93

Serum levels of interleukin-1 beta associate better with severity of simple steatosis than liver function tests in morbidly obese patients


1 Research Division, Laboratory for Proteomics and Metabolomics, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico
2 Department of Genetics, Clinic for Obesity, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico

Correspondence Address:
Dr. Galileo Escobedo
Research Division, Laboratory for Proteomics and Metabolomics, General Hospital of Mexico “Dr. Eduardo Liceaga”, 06726, Mexico City
Mexico
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_142_18

Rights and Permissions

Background: In high-fat diet-fed mice, interleukin-1 beta (IL-1 beta) has been shown to play a key role in hepatic steatosis. However, it remains unknown whether IL-1 beta could be associated with different grades of steatosis in obese humans. Materials and Methods: Morbidly obese patients (n = 124) aged 18–65 years were divided into four groups: no steatosis (controls), mild steatosis, moderate steatosis, and severe steatosis using abdominal ultrasound. IL-1 beta serum levels and liver function tests were measured and significant differences were estimated by one-way ANOVA followed by Tukey test. Results: IL-1 beta serum levels significantly increased in morbidly obese patients with mild (11.38 ± 2.40 pg/ml), moderate (16.72 ± 2.47 pg/ml), and severe steatosis (23.29 ± 5.2 pg/ml) as compared to controls (7.78 ± 2.26 pg/ml). Liver function tests did not significantly change among different grades of steatosis. Conclusion: IL-1 beta serum levels associate better with steatosis degree than liver function tests in morbidly obese population.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed237    
    Printed18    
    Emailed0    
    PDF Downloaded57    
    Comments [Add]    

Recommend this journal