Home About us Editorial board Ahead of print Browse Articles Search Submit article Instructions Subscribe Contacts Login 
  • Users Online: 1687
  • Home
  • Print this page
  • Email this page
Year : 2018  |  Volume : 23  |  Issue : 1  |  Page : 48

Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, People's Republic of China

Correspondence Address:
Dr. Jin-Hua Xu
Department of Dermatology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040
People's Republic of China
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jrms.JRMS_1038_16

Rights and Permissions

Background: Significance of platelet distribution width(PDW) and mean platelet volume(MPV) in assessing disease activity of systemic lupus erythematosus(SLE) remains unclear. This study was aimed to evaluate PDW and MPV as potential disease activity markers in adult SLE patients. Materials and Methods: A total of 204 study participants, including 91 SLE patients and 113 age-and gender-matched healthy controls, were selected in this cross-sectional study. They were classified into three groups: control group(n=113), active SLE group(n=54), and inactive SLE group(n=37). Demographic, clinical, and laboratory data were analyzed. Results: In patient group, PDW was statistically higher than that in control group(13.54±2.67vs. 12.65±2.34, P=0.012), and in active group, PDW was significantly increased compared to inactive group(14.31±2.90vs. 12.25±1.55, P <0.001). However, MPV was significantly lower in SLE group than in control group(10.74±0.94vs. 11.09±1.14, P=0.016). PDW was positively correlated with SLE disease activity index(P<0.001, r=0.529) and erythrocyte sedimentation rate(P=0.002, r=0.321) and negatively correlated with C3(P<0.001, r = −0.419). However, there was no significant association between MPV and these study variables. APDW level of 11.85% was determined as a predictive cutoff value of SLE diagnosis(sensitivity 76.9%, specificity 42.5%) and 13.65% as cutoff of active stage(sensitivity 52.6%, specificity 85.3%). Conclusion: This study first associates a higher PDW level with an increased SLE activity, suggesting PDW as a novel indicator to monitor the activity of SLE.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded255    
    Comments [Add]    
    Cited by others 3    

Recommend this journal