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LETTER TO EDITOR
J Res Med Sci 2018,  23:46

Hyperimmunoglobulin E syndrome


Department of Allergy and Clinical Immunology, Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran

Date of Web Publication30-May-2018

Correspondence Address:
Prof. Javad Ghaffari
Department of Allergy and Clinical Immunology, Bou Ali Sina Hospital, Mazandaran University of Medical Sciences, Pasdaran Boulevard, Sari, Mazandaran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_40_18

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How to cite this article:
Ghaffari J. Hyperimmunoglobulin E syndrome. J Res Med Sci 2018;23:46

How to cite this URL:
Ghaffari J. Hyperimmunoglobulin E syndrome. J Res Med Sci [serial online] 2018 [cited 2018 Dec 13];23:46. Available from: http://www.jmsjournal.net/text.asp?2018/23/1/46/233507



Hashemi et al. recently published an article with title: Hyperimmunoglobulin E syndrome: Genetics, immunopathogenesis, clinical findings, and treatment modalities in your journal that it is a good paper.[1] Despite without limitation for searching, there are not a few of related papers in their working.

Incidence of hyperimmunoglobulin E syndrome(HIGE) is 1/100,000–1/200,000. This syndrome divided into two groups including autosomal dominant with a mutation in signal transducer and activator of transcription-3(chromosome 17, MIM=147,060) Type1 and autosomal recessive with a mutation in dedicator of cytokinesis 8(chromosome 9, MIM=243,700)(Type2).[2]

Mutations of autosomal recessive HIES-like disorders following:

  1. Tyrosine kinase 2 gene, encoded on chromosome 19p13.2(MIM #611521)
  2. Phosphoglucomutase 3 gene, which encodes an enzyme in the biosynthesis of N-glycans(MIM #615816).[2]


About skin manifestations of HIGE syndrome, we reported a boy(16years old) of HIGE presented with skin psoriasis disease from 1year ago. His history was recurrent infections including otitis media, pneumonia, diarrhea, and skin infection. Histologic finding was hyperkeratosis, parakeratosis of acanthotic epidermis with regular elongation of rete ridges.

This is the first report of association or relation between hyperactive immunoglobulin E immunoglobulinemia and psoriasis disorder.[3]

We reported another case of HIGE with recurrent infections and pneumatocele in the left and right of the lung. Because there were multiple large pneumatoceles, there was no possible surgery.[4]

The role of bone marrow transplant has different results. Hematopoietic stem cell transplantation(HSCT) was done for different kinds of HIES, but information and experience about the long-term results of this therapy are little.[2]

Recently, studies suggest that HSCT can improve immunologic parameters and reduce frequency and severity of infections although nonhematologic organ failures are not corrected.[5]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
HashemiH, MohebbiM, MehravaranS, MazloumiM, Jahanbani-ArdakaniH, AbtahiSH, etal. Hyperimmunoglobulin E syndrome: Genetics, immunopathogenesis, clinical findings, and treatment modalities. JRes Med Sci 2017;22:53.  Back to cited text no. 1
    
2.
GhaffariJ, AhanchianH, ZandiehF. Update on hyper IgE syndrome(HIES). JPediatr Rev 2014;2:39-46.  Back to cited text no. 2
    
3.
GhaffariJ, Abedian-KenariS, GhasemiM, GohardehiF. Psoriasis in hyper IgE syndrome–A case report. Caspian J Intern Med 2013;4:735-8.  Back to cited text no. 3
    
4.
GhaffariJ, GharagozlooM, NazariZ. Acase report of hyper IgE syndrome. JMazand Univ Med Sci 2007;16:155-60.  Back to cited text no. 4
    
5.
YanagimachiM, OhyaT, YokosukaT, KajiwaraR, TanakaF, GotoH, etal. The potential and limits of hematopoietic stem cell transplantation for the treatment of autosomal dominant hyper-IgE syndrome. JClin Immunol 2016;36:511-6.  Back to cited text no. 5
    




 

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