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ORIGINAL ARTICLE
Year : 2018  |  Volume : 23  |  Issue : 1  |  Page : 22

Correlation between Vitamin D3 level and extrahepatic manifestation in chronic hepatitis type-C virus patients


1 Department of Gastroenterology, Liver and Gastrointestinal Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Endocrinology, Gilan University of Medical Sciences, Rasht, Iran
4 Department of Gastroenterology, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Infectious Diseases, Isfahan Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Dr. Javad Golpayegani
Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_366_17

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Background: Chronic hepatitis type-C virus (HCV) infection is one of the most common worldwide viral disorders, which leads to various clinical complications as well as extrahepatic manifestations. Furthermore, Vitamin D3 has also been reported to have relationship with the mentioned complications. The aim is to evaluate the correlation between Vitamin D3 level and extrahepatic manifestation in chronic HCV patients. Materials and Methods: This cross-sectional study has been carried out on 90 patients with chronic hepatitis C. The level of Vitamin D3 was assessed in plasma of 90 patients with chronic HCV. Genotyping was done and clinical and sign and symptoms of recruited patients were gathered. Extrahepatic manifestations were evaluated and the correlation of blood, hepatic, and immunological factors and the level of Vitamin D3 were assessed. Results: Most of our patients were male (92% vs. 8%). Twenty-nine percent had the insufficient amount of Vitamin D3 (21–30 ng/ml), and the remains had the Vitamin D3 level between 13–20 ng/ml. Furthermore, our assessment demonstrated that deficiency of Vitamin D3 was associated with the extrahepatic manifestations such as purpura (odds radio [OR] [95% confidence interval (CI) 95%] = 8.80 [1.74–44.47], P = 0.004), vasculitis (OR [95% CI] = 11.70 [3.01–45.41], P < 0.001), arthralgia (OR [95% CI] = 20.26 [4.21–97.47], P < 0.001), myalgia (OR [95% CI] = 4.00 [1.01–17.27], P = 0.048), and glomerulonephritis (P = 0.021). Conclusion: According to our results, the extrahepatic manifestation in the patients with sufficient levels of Vitamin D3 would be less possible. In fact, it could be stated that deficiency in the Vitamin D3 can have a significant relationship with these manifestations.


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