Home About us Editorial board Ahead of print Browse Articles Search Submit article Instructions Subscribe Contacts Login 
  • Users Online: 141
  • Home
  • Print this page
  • Email this page


 
Previous article Browse articles Next article 
LETTER TO EDITOR
J Res Med Sci 2018,  23:20

Methylenetetrahydrofo late reductase C677T polymorphism and schizophrenia: Effect of molecular change


1 KMT Primary Care Center, Bangkok, Thailand
2 Tropical Medicine, Hainan Medical University, Haikou, China

Date of Web Publication27-Mar-2018

Correspondence Address:
Dr. Sora Yasri
KMT Primary Care Center, Bangkok
Thailand
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_915_17

Rights and Permissions

How to cite this article:
Yasri S, Wiwanitkit V. Methylenetetrahydrofo late reductase C677T polymorphism and schizophrenia: Effect of molecular change. J Res Med Sci 2018;23:20

How to cite this URL:
Yasri S, Wiwanitkit V. Methylenetetrahydrofo late reductase C677T polymorphism and schizophrenia: Effect of molecular change. J Res Med Sci [serial online] 2018 [cited 2018 Dec 14];23:20. Available from: http://www.jmsjournal.net/text.asp?2018/23/1/20/228592



Sir,

Schizophrenia is an important psychological disorder. There are many reports on the underlying medical and genetic underlying factors of schizophrenia. Malhotra et al. recently noted that“there is some evidence to suggest an association of MetS with adiponectin levels, hematological indices, methylenetetrahydrofolate reductase (MTHFR), and Alpha-1A adrenergic receptor gene.[1]” Focusing on MTHFR, Yadav et al. performed meta-analysis study and suggested that “the MTHFR C677T polymorphism is a risk factor for schizophrenia.[2]” Here, the authors would like to discuss on the effect of MTHFR C677T polymorphism based on basic consideration on nanomolecular weight change. Theoretically, the molecule with polymorphism will have altered molecular weight that might affect the biological process. Using the quantum calculation technique as previously reported in the previous publications,[3],[4],[5] it can be seen that the C677T polymorphism has a lower molecular weight than wild-type (decreased mass = 2). Per one molecule, the decreased molecular weight in the mutated polymorphism will result in a less mass of final biochemical product comparing to naïve type. Indeed, this finding is concordant with a previous observation that MTHFR deficit could induce schizophrenia.[6] The important key message is the decreased molecular mass in C677T polymorphism can imply reduced MTHFR activity that can be an explanation for the observed relationship to schizophrenia.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Malhotra N, Grover S, Chakrabarti S, Kulhara P. Metabolic syndrome in schizophrenia. Indian J Psychol Med 2013;35:227-40.  Back to cited text no. 1
[PUBMED]  [Full text]  
2.
Yadav U, Kumar P, Gupta S, Rai V. Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis. Asian J Psychiatr 2016;20:41-51.  Back to cited text no. 2
    
3.
Joob B, Wiwanitkit V. HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: Quantum chemical analysis and implication in patients with renal transplantation. J Nephropharmacol 2017;6:19-20.  Back to cited text no. 3
    
4.
Joob B, Wiwanitkit V. ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) polymorphism and clopidogrel concentration in acute coronary syndrome: Molecular change can explain the observed therapeutic concentration. Anatol J Cardiol 2016;16:303-4.  Back to cited text no. 4
    
5.
Wiwanitkit S, Wiwanitkit V. Change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and susceptibility to antimalarial drug: Possible role of epigenetic phenomenon. Asian Pac J Trop Biomed 2017;7:181-2.  Back to cited text no. 5
    
6.
Wang Q, Liu J, Liu YP, Li XY, Ma YY, Wu TF, et al. Methylenetetrahydrofolate reductase deficiency-induced schizophrenia in a school-age boy. Zhongguo Dang Dai Er Ke Za Zhi 2014;16:62-6.  Back to cited text no. 6
    



This article has been cited by
1 Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds
Beuy Joob,Viroj Wiwanitkit
Journal of Occupational and Environmental Medicine. 2018; 60(10): e559
[Pubmed] | [DOI]



 

Top
Previous article  Next article
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
References

 Article Access Statistics
    Viewed326    
    Printed4    
    Emailed0    
    PDF Downloaded42    
    Comments [Add]    
    Cited by others 1    

Recommend this journal