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ORIGINAL ARTICLE
Year : 2017  |  Volume : 22  |  Issue : 1  |  Page : 128

Effect of Nepeta bracteata Benth. on allergic rhinitis symptoms: A randomized double-blind clinical trial


1 Department of Traditional ian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
2 Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Shahed University, Tehran, Iran
3 Department of Health and Social Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
4 Traditional Medicine Clinical Trial Research Center; Department of Traditional ian Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
5 Department of Otolaryngology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
6 Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
7 Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran

Correspondence Address:
Mohsen Naseri
Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jrms.JRMS_316_17

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Background: Allergic rhinitis (AR) is one of the health problems in the world. It is necessary to develop new treatment procedure for control of this disease. The aim of this study was to assess the effect of Zofa (Nepeta bracteata Benth) on AR patients. Materials and Methods: In this double-blind randomized clinical trial study, 71 patients (37 patients in treatment and 34 in placebo group) participated. In treatment group, N. bracteata syrup (NBS) was used for 4 weeks as three times a day. The efficacy of the drug regarding AR symptoms (rhinorrhea, sneezing, nasal obstruction, itchy nose, and ocular symptoms) were evaluated through a visual analog scale (VAS) by 0–10 before administration and at the end of the whole treatment period. The collected information was entered in the SPSS software (version 18) and was analyzed using the Fisher's exact test, Chi-square test, independent sample t-test, and paired sample test. Results: The improvement of AR symptoms in the group receiving NBS was significantly higher compared to control group (4.73 ± 1.84 vs. 0.38 ± 2.06; P < 0.0001). Furthermore, the mean of total VAS before and after the treatment (in case group) was 7.10 ± 1.92 and 2.37 ± 1.76, respectively (P < 0.001). Conclusion: The results of this study indicate that N. bracteata has significant effects on improving the symptoms of AR. Hence, it can be a good alternative to AR symptoms relief.


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